Gut microbiota-dependent adaptor molecule recruits DNA methyltransferase to the TLR4 gene in colonic epithelial cells to suppress inflammatory reactions

Gut microbiota-dependent adaptor molecule recruits DNA methyltransferase to the TLR4 gene in colonic epithelial cells to suppress inflammatory reactions

The intestine is inhabited by a large number of commensal bacteria that are immunologically non-self, potentially causing inflammation. However, in a healthy intestine, inflammation is strictly controlled at low levels to maintain homeostasis. We previously reported that the gut microbiota induce DN...

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Bibliographic Details
Main Authors: Hikari Narabayashi, Chiharu Koma, Kazuaki Nakata, Mion Ikegami, Yusuke Nakanishi, Jun Ogihara, Masato Tsuda, Akira Hosono, Shigemasa Hanazawa, Kyoko Takahashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
gut microbiota
intestinal epithelial cell
TLR4
DNA methyltransferase
RBM14
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1005136/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1005136/full

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