Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated genes. The HIRA gene lies within the 22q11.2 dele...

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Bibliographic Details
Main Authors: Nicolas Valenzuela, Qiying Fan, Faisal Fa'ak, Benjamin Soibam, Harika Nagandla, Yu Liu, Robert J. Schwartz, Bradley K. McConnell, M. David Stewart
Format: Article
Language:English
Published: The Company of Biologists 2016-03-01
Series:Disease Models & Mechanisms
Subjects:
HIRA
Heart
H3.3
Cardiomyocyte
Histone
Online Access:http://dmm.biologists.org/content/9/3/335

Internet

http://dmm.biologists.org/content/9/3/335

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