Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs

Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs

Multivalent antibody constructs have a broad range of clinical and biotechnological applications. Nanobodies are especially useful as components for multivalent constructs as they allow increased valency while maintaining a small molecule size. We here describe a novel, rapid method for the generati...

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Bibliographic Details
Main Authors: Ainhoa Moliner-Morro, Daniel J. Sheward, Vivien Karl, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Leo Hanke
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
single-domain antibody fragment
nanobody
neutralization
sortase A
click chemistry
PEG linker
Online Access:https://www.mdpi.com/2218-273X/10/12/1661

Internet

https://www.mdpi.com/2218-273X/10/12/1661

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