Abstract OR-12: Cryo-EM of Human and Parasite Proteasomes for Structure-Based Drug Design

Background: The increasing spread of Plasmodium falciparum resistance to current antimalarials, including the frontline artemisinin and its derivatives, represents a major global threat to human health and urges the development of novel medicaments. For many years, proteasomal inhibition by specific...

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Bibliographic Details
Main Authors: Pavel Afanasyev, Euna Yoo, Matthew Bogyo, Paula C.A. da Fonseca
Format: Article
Language:English
Published: International Medical Research and Development Corporation 2019-06-01
Series:International Journal of Biomedicine
Subjects:
Online Access:http://ijbm.org/articles/IJBM_2019_9_S1_OR12.pdf