Activation of TRPA1 in Bladder Suburothelial Myofibroblasts Counteracts TGF-β1-Induced Fibrotic Changes

Activation of TRPA1 in Bladder Suburothelial Myofibroblasts Counteracts TGF-β1-Induced Fibrotic Changes

The activation of the transient receptor potential ankyrin 1 (TRPA1) channel has anti-fibrotic effects in the lung and intestine. Suburothelial myofibroblasts (subu−MyoFBs), a specialized subset of fibroblasts in the bladder, are known to express TRPA1. However, the role of the TRPA1 in the developm...

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Bibliographic Details
Main Authors: Mengmeng Zhao, Ning Ding, Haoyu Wang, Shulu Zu, Hanwen Liu, Jiliang Wen, Jiaxin Liu, Nan Ge, Wenzhen Wang, Xiulin Zhang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
bladder fibrosis
TRPA1 channel
TGF-β1
myofibroblasts
allylisothiocyanate
SCI
Online Access:https://www.mdpi.com/1422-0067/24/11/9501

Internet

https://www.mdpi.com/1422-0067/24/11/9501

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