Novel Opipramol-Baclofen Combination Alleviates Depression and Craving and Facilitates Recovery From Substance Use Disorder—An Animal Model and a Human Study

Novel Opipramol-Baclofen Combination Alleviates Depression and Craving and Facilitates Recovery From Substance Use Disorder—An Animal Model and a Human Study

Substance use disorders (SUDs) are associated with depression and anxiety, with the latter being one of the major factors in substance-seeking and relapse. Due to dose-dependent sedative side effects there is limited efficacy of baclofen treatment for SUDs. Here we suggest the use of a novel combina...

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Bibliographic Details
Main Authors: Tzofnat Bareli, Hadas Levi Ahdoot, Hila Ben Moshe, Royi Barnea, Gal Warhaftig, Iris Gispan, Rachel Maayan, Paola Rosca, Abraham Weizman, Gal Yadid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
stress
substance-induced depressive disorder
addiction
treatment
therapeutic center
baclofen
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.788708/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2021.788708/full

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