Accounting for parameter uncertainty in the definition of parametric distributions used to describe individual patient variation in health economic models

Accounting for parameter uncertainty in the definition of parametric distributions used to describe individual patient variation in health economic models

Abstract Background Parametric distributions based on individual patient data can be used to represent both stochastic and parameter uncertainty. Although general guidance is available on how parameter uncertainty should be accounted for in probabilistic sensitivity analysis, there is no comprehensi...

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Bibliographic Details
Main Authors: Koen Degeling, Maarten J. IJzerman, Miriam Koopman, Hendrik Koffijberg
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Medical Research Methodology
Subjects:
Patient-level variation
Stochastic uncertainty
Parameter uncertainty
State-transition modeling
Discrete event simulation
Personalized medicine
Online Access:http://link.springer.com/article/10.1186/s12874-017-0437-y

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http://link.springer.com/article/10.1186/s12874-017-0437-y

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