CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice

CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and triglyceride (TG) levels and decreased glucose levels. Studies in spontaneous hypertensive rats lacking functional CD36 link CD36 to the insulin-res...

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Bibliographic Details
Main Authors: Jeltje R. Goudriaan, Vivian E.H. Dahlmans, Bas Teusink, D. Margriet Ouwens, Maria Febbraio, J. Anton Maassen, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Journal of Lipid Research
Subjects:
fatty acid transport
glucose metabolism
hepatic steatosis
hyperinsulinemic clamp
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319441

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http://www.sciencedirect.com/science/article/pii/S0022227520319441

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