Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new Mendelian Randomization method to estimate bi- directional causal effects and explicitly account for heritable confounding.

Bibliographic Details
Main Authors: Liza Darrous, Ninon Mounier, Zoltán Kutalik
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26970-w

Internet

https://doi.org/10.1038/s41467-021-26970-w

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