Early-life propofol exposure does not affect later-life GABAergic inhibition, seizure induction, or social behavior

Early-life propofol exposure does not affect later-life GABAergic inhibition, seizure induction, or social behavior

The early developing brain is especially vulnerable to anesthesia, which can result in long lasting functional changes. We examined the effects of early-life propofol on adult excitatory-inhibitory balance and behavior. Postnatal day 7 male mice were exposed to propofol (250 mg/kg i.p.) and anesthes...

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Bibliographic Details
Main Authors: Jinyang Liu, Daisy Lin, Alice Yau, James E. Cottrell, Ira S. Kass
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:IBRO Neuroscience Reports
Subjects:
Propofol
Early-life anesthesia
Brain development
GABAergic inhibition
Social behavior
Cognitive function
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242123000441

Internet

http://www.sciencedirect.com/science/article/pii/S2667242123000441

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