Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State

Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State

The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important functions both in the neural system and during embryonic development in mammals. In this study, we set out to investigate whether and how endogenous serotonin affects reprogramming to pluripotency. As serotonin is syn...

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Bibliographic Details
Main Authors: Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Sergey V. Ponomartsev, Evgeniya V. Efimova, Michael Bader, Natalia Alenina, Alexey N. Tomilin
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
serotonin
5-HT
pluripotency
reprogramming
induced pluripotent stem cells (iPSCs)
tryptophan hydroxylase 1 and 2 (TPH1 and TPH2)
Online Access:https://www.mdpi.com/1422-0067/24/5/4862

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https://www.mdpi.com/1422-0067/24/5/4862

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