In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing

In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing

BackgroundThe core circadian gene Neuronal PAS domain 2 (NPAS2) is expressed in dermal fibroblasts and has been shown to play a critical role in regulating collagen synthesis during wound healing. We have performed high throughput drug screening to identify genes responsible for downregulation of Np...

Full description

Bibliographic Details
Main Authors: Adam Clements, Yoichiro Shibuya, Akishige Hokugo, Zachary Brooks, Yvonne Roca, Takeru Kondo, Ichiro Nishimura, Reza Jarrahy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Medicine
Subjects:
wound healing
skin
scarring
circadian clock
fibroblast
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1014763/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.1014763/full

Similar Items