Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease

Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease

Neurodegenerative diseases represent promising targets for gene therapy approaches provided effective transfer vectors. In the present study, we evaluated the effectiveness of LacZ-expressing lentiviral vectors with two different internal promoters, the mouse phosphoglycerate kinase 1 (PGK) and cyto...

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Bibliographic Details
Main Authors: L.Pereira de Almeida, D. Zala, P. Aebischer, N. Déglon
Format: Article
Language:English
Published: Elsevier 2001-06-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
lentiviral vector
gene therapy
ciliary neurotrophic factor
quinolinic acid lesion model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101903882

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http://www.sciencedirect.com/science/article/pii/S0969996101903882

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