Evaluation of Collagen Alterations in Early Precursor Lesions of High Grade Serous Ovarian Cancer by Second Harmonic Generation Microscopy and Mass Spectrometry

Evaluation of Collagen Alterations in Early Precursor Lesions of High Grade Serous Ovarian Cancer by Second Harmonic Generation Microscopy and Mass Spectrometry

<b>Background:</b> The collagen architecture in high grade serous ovarian cancer (HGSOC) is highly remodeled compared to the normal ovary and the fallopian tubes (FT). We previously used Second Harmonic Generation (SHG) microscopy and machine learning to classify the changes in collagen...

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Bibliographic Details
Main Authors: Kristal L. Gant, Alexander N. Jambor, Zihui Li, Eric C. Rentchler, Paul Weisman, Lingjun Li, Manish S. Patankar, Paul J. Campagnola
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
HGSOC
STICs
precursor lesions
Second Harmonic Generation
collagen remodeling
mass spectrometry
Online Access:https://www.mdpi.com/2072-6694/13/11/2794

Internet

https://www.mdpi.com/2072-6694/13/11/2794

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