Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine.

Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine.

Extracellular adenosine (ADE) interacts with cells by two pathways: by activating cell surface receptors at nanomolar/micromolar concentrations; and by interfering with the homeostasis of the intracellular nucleotide pool at millimolar concentrations. Ade shows both cytotoxic and cytoprotective effe...

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Bibliographic Details
Main Authors: Shujue Li, Xiaofen Li, Haiping Guo, Shouting Liu, Hongbiao Huang, Ningning Liu, Changshan Yang, Ping Tang, Jinbao Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3789704?pdf=render

Internet

http://europepmc.org/articles/PMC3789704?pdf=render

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