Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters

Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters

Potassium channels and membrane potential may influence macrophage function during inflammation. Here the authors show that the Kir2.1 potassium channel affects macrophage metabolism by altering cell surface retention of nutrient transporters and subsequently regulates inflammatory disease responses...

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Bibliographic Details
Main Authors: Weiwei Yu, Zhen Wang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang, Di Wang
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31149-y

Internet

https://doi.org/10.1038/s41467-022-31149-y

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