MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders. Here, we measured miR-223 expression in acute and intercritical gout patients, after which we used RAW264.7 macrophages transfected wit...

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Bibliographic Details
Main Authors: Quan-Bo Zhang, Dan Zhu, Fei Dai, Yu-Qin Huang, Jian-Xiong Zheng, Yi-Ping Tang, Zeng-Rong Dong, Xia Liao, Yu-Feng Qing
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
microrna-223
gout
inflammation
cytokines
inflammasome
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.637415/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.637415/full

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