High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

ABSTRACT Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that affords elevated, sustained, and cross-variant SARS-CoV-2 neutralizing a...

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Bibliographic Details
Main Authors: Claudio Counoupas, Paco Pino, Alberto O. Stella, Caroline Ashley, Hannah Lukeman, Nayan D. Bhattacharyya, Takuya Tada, Stephanie Anchisi, Charles Metayer, Jacopo Martinis, Anupriya Aggarwal, Belinda M. Dcosta, Warwick J. Britton, Joeri Kint, Maria J. Wurm, Nathaniel R. Landau, Megan Steain, Stuart G. Turville, Florian M. Wurm, Sunil A. David, James A. Triccas
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
COVID-19
vaccination
subunit vaccine
variant
adjuvant
immune response
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01695-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.01695-21

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