A 3-O-sulfated heparan sulfate dodecasaccharide (12-mer) suppresses thromboinflammation and attenuates early organ injury following trauma and hemorrhagic shock

A 3-O-sulfated heparan sulfate dodecasaccharide (12-mer) suppresses thromboinflammation and attenuates early organ injury following trauma and hemorrhagic shock

IntroductionDysregulated inflammation and coagulation are underlying mechanisms driving organ injury after trauma and hemorrhagic shock. Heparan sulfates, cell surface glycosaminoglycans abundantly expressed on the endothelial surface, regulate a variety of cellular processes. Endothelial heparan su...

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Bibliographic Details
Main Authors: Maria del Pilar Huby Vidaurre, Baron K. Osborn, Kaylie D. Lowak, Michelle M. McDonald, Yao-Wei W. Wang, Veda Pa, Jillian R. Richter, Yongmei Xu, Katelyn Arnold, Jian Liu, Jessica C. Cardenas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
thromboinflammation
heparan sulfate
traumatic injury
hemorrhagic shock
organ injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158457/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158457/full

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