Comparative Assessment and High-Throughput Drug-Combination Profiling of TEAD-Palmitoylation Inhibitors in Hippo Pathway Deficient Mesothelioma

Comparative Assessment and High-Throughput Drug-Combination Profiling of TEAD-Palmitoylation Inhibitors in Hippo Pathway Deficient Mesothelioma

The hippo signaling pathway is a central tumor suppressor cascade frequently inactivated in selected human cancers, leading to the aberrant activation of TEAD transcription factors. Whereas several TEAD auto-palmitoylation inhibitors are currently in development, a comprehensive assessment of this n...

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Bibliographic Details
Main Authors: Lale Evsen, Patrick J. Morris, Craig J. Thomas, Michele Ceribelli
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
TEAD
TEAD-palmitoylation
TEAD inhibitors
high-throughput drug screening
drug combination
Hippo signaling
Online Access:https://www.mdpi.com/1424-8247/16/12/1635

Internet

https://www.mdpi.com/1424-8247/16/12/1635

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