Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affect drug-metabolizing cytochrome P450 activities. E...

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Bibliographic Details
Main Authors: Shaheena Parween, Maria Natalia Rojas Velazquez, Sameer S. Udhane, Norio Kagawa, Amit V. Pandey
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
POR
P450 oxidoreductase
CYP2C9
CYP2C19
CYP3A4
CYP3A5
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01187/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01187/full

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