Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors

Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors

Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family could provide a novel approach to alleviate the in...

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Bibliographic Details
Main Authors: Afaf A. El-Malah, Magdy M. Gineinah, Maan T. Khayat, Anfal S. Aljahdali, Marwa M. Safar, Hadeel A. Almazmumi, Roaa M. Khinkar
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
phosphodiesterase 7 inhibitors
hydrazinoquinazolines
triazoloquinazolines anti-inflammatory
molecular docking
molecular dynamic
in vitro assay
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1389076/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1389076/full

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