Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway

Abstract Background Hypoxia is associated with many respiratory diseases, partly due to the accumulation of edema fluid and mucus on the surface of alveolar epithelial cell (AEC), which forms oxygen delivery barriers and is responsible for the disruption of ion transport. Epithelial sodium channel (...

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Bibliographic Details
Main Authors: Wei Zhou, Yapeng Hou, Tong Yu, Tingyu Wang, Yan Ding, Hongguang Nie
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-023-02428-z