Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats

Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats

Allyl isothiocyanate (AITC) activates transient receptor potential ankyrin 1 (TRPA1) channel, which is involved in the control of intestinal mucosal blood flow. However, the mechanism underlying the increased gastric mucosal blood flow (GMBF) in response to AITC remains unknown. We examined the effe...

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Bibliographic Details
Main Authors: Noriyuki Ohashi, Kimihito Tashima, Takao Namiki, Syunji Horie
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Allyl isothiocyanate
TRPA1
Rats
Calcitonin gene-related peptide
Gastric mucosal blood flow
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000075

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http://www.sciencedirect.com/science/article/pii/S1347861323000075

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