Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells

Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells

Cataract, an opacification in the crystalline lens, is a leading cause of blindness. Deposition of hydroxyapatite occurs in a cataractous lens that could be the consequence of osteogenic differentiation of lens epithelial cells (LECs). Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the...

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Bibliographic Details
Main Authors: Arpan Chowdhury, Enikő Balogh, Haneen Ababneh, Andrea Tóth, Viktória Jeney
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
cataract
lens epithelial cells
osteogenic differentiation
lens calcification
nuclear factor erythroid 2-related factor 2 (Nrf2)
heme
Online Access:https://www.mdpi.com/1424-8247/15/5/493

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https://www.mdpi.com/1424-8247/15/5/493

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