Integrated analysis of scRNA-seq and bulk RNA-seq identifies FBXO2 as a candidate biomarker associated with chemoresistance in HGSOC

Integrated analysis of scRNA-seq and bulk RNA-seq identifies FBXO2 as a candidate biomarker associated with chemoresistance in HGSOC

Background: High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and aggressive histological subtype of epithelial ovarian cancer. Around 80% of individuals will experience a recurrence within five years because of resistance to chemotherapy, despite initially responding well to platinu...

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Bibliographic Details
Main Authors: Wenwen Lai, Ruixiang Xie, Chen Chen, Weiming Lou, Haiyan Yang, Libin Deng, Quqin Lu, Xiaoli Tang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
High-grade serous ovarian carcinoma
Chemoresistance
Biomarker
Single-cell RNA-seq
Bulk RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024045213

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http://www.sciencedirect.com/science/article/pii/S2405844024045213

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