Structure–activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Structure–activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Abstract The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association with invasive disease, little is known about enzymatic function beyond the ELR+ CXC chemokine substrate range. As a serine protease, SpyC...

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Bibliographic Details
Main Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J. Jones, Mark Reglinski, Lucy Reeves, Robert J. Edwards, Richard Ashley Lawrenson, Jonathan C. Brown, Danuta Mossakowska, James Edward Pease, Shiranee Sriskandan
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-46036-9

Internet

https://doi.org/10.1038/s41598-023-46036-9

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