Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Abstract Background Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs f...

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Bibliographic Details
Main Authors: Tatiana Rodrigues Alexandre, Marta Lopes Lima, Mariana Kolos Galuppo, Juliana Tonini Mesquita, Matilia Ana do Nascimento, Augusto Leonardo dos Santos, Patricia Sartorelli, Daniel Carvalho Pimenta, Andre Gustavo Tempone
Format: Article
Language:English
Published: SciELO 2017-05-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Pleurotus salmoneostramineus
Ergosterol
Trypanosoma cruzi
Mechanism of action
Online Access:http://link.springer.com/article/10.1186/s40409-017-0120-0

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http://link.springer.com/article/10.1186/s40409-017-0120-0

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