Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth
Poly(methyl methacrylate) (PMMA) is the most frequently used bone void filler in orthopedic surgery. However, the interface between the PMMA-based cement and adjacent bone tissue is typically weak as PMMA bone cement is inherently bioinert and not ideal for bone ingrowth. The present study aims to i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2019-05-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.182060 |
| _version_ | 1818151324417523712 |
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| author | Kuan-Lin Ku Yu-Shan Wu Chi-Yun Wang Ding-Wei Hong Zong-Xing Chen Ching-An Huang I-Ming Chu Po-Liang Lai |
| author_facet | Kuan-Lin Ku Yu-Shan Wu Chi-Yun Wang Ding-Wei Hong Zong-Xing Chen Ching-An Huang I-Ming Chu Po-Liang Lai |
| author_sort | Kuan-Lin Ku |
| collection | DOAJ |
| description | Poly(methyl methacrylate) (PMMA) is the most frequently used bone void filler in orthopedic surgery. However, the interface between the PMMA-based cement and adjacent bone tissue is typically weak as PMMA bone cement is inherently bioinert and not ideal for bone ingrowth. The present study aims to improve the affinity between the polymer and ceramic interphases. By surface modifying nano-sized hydroxyapatite (nHAP) with ethylene glycol and poly(ɛ-caprolactone) (PCL) sequentially via a two-step ring opening reaction, affinity was improved between the polymer and ceramic interphases of PCL-grafted ethylene glycol-HAP (gHAP) in PMMA. Due to better affinity, the compressive strength of gHAP/PMMA was significantly enhanced compared with nHAP/PMMA. Furthermore, PMMA with 20 wt.% gHAP promoted pre-osteoblast cell proliferation in vitro and showed the best osteogenic activity between the composites tested in vivo. Taken together, gHAP/PMMA not only improves the interfacial adhesion between the nanoparticles and cement, but also increases the biological activity and affinity between the osteoblast cells and PMMA composite cement. These results show that gHAP and its use in polymer/bioceramic composite has great potential to improve the functionality of PMMA cement. |
| first_indexed | 2024-12-11T13:37:01Z |
| format | Article |
| id | doaj.art-21841a5301104735b008d57e7d968154 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-11T13:37:01Z |
| publishDate | 2019-05-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-21841a5301104735b008d57e7d9681542022-12-22T01:04:58ZengThe Royal SocietyRoyal Society Open Science2054-57032019-05-016510.1098/rsos.182060182060Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowthKuan-Lin KuYu-Shan WuChi-Yun WangDing-Wei HongZong-Xing ChenChing-An HuangI-Ming ChuPo-Liang LaiPoly(methyl methacrylate) (PMMA) is the most frequently used bone void filler in orthopedic surgery. However, the interface between the PMMA-based cement and adjacent bone tissue is typically weak as PMMA bone cement is inherently bioinert and not ideal for bone ingrowth. The present study aims to improve the affinity between the polymer and ceramic interphases. By surface modifying nano-sized hydroxyapatite (nHAP) with ethylene glycol and poly(ɛ-caprolactone) (PCL) sequentially via a two-step ring opening reaction, affinity was improved between the polymer and ceramic interphases of PCL-grafted ethylene glycol-HAP (gHAP) in PMMA. Due to better affinity, the compressive strength of gHAP/PMMA was significantly enhanced compared with nHAP/PMMA. Furthermore, PMMA with 20 wt.% gHAP promoted pre-osteoblast cell proliferation in vitro and showed the best osteogenic activity between the composites tested in vivo. Taken together, gHAP/PMMA not only improves the interfacial adhesion between the nanoparticles and cement, but also increases the biological activity and affinity between the osteoblast cells and PMMA composite cement. These results show that gHAP and its use in polymer/bioceramic composite has great potential to improve the functionality of PMMA cement.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.182060bone cementbiocompatibilityhydroxyapatitepoly(ɛ-caprolactone)poly(methyl methacrylate)surface grafting |
| spellingShingle | Kuan-Lin Ku Yu-Shan Wu Chi-Yun Wang Ding-Wei Hong Zong-Xing Chen Ching-An Huang I-Ming Chu Po-Liang Lai Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth Royal Society Open Science bone cement biocompatibility hydroxyapatite poly(ɛ-caprolactone) poly(methyl methacrylate) surface grafting |
| title | Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth |
| title_full | Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth |
| title_fullStr | Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth |
| title_full_unstemmed | Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth |
| title_short | Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth |
| title_sort | incorporation of surface modified hydroxyapatite into poly methyl methacrylate to improve biological activity and bone ingrowth |
| topic | bone cement biocompatibility hydroxyapatite poly(ɛ-caprolactone) poly(methyl methacrylate) surface grafting |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.182060 |
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