Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation...

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Bibliographic Details
Main Authors: Jack D. Adderley, Simona John von Freyend, Sarah A. Jackson, Megan J. Bird, Amy L. Burns, Burcu Anar, Tom Metcalf, Jean-Philippe Semblat, Oliver Billker, Danny W. Wilson, Christian Doerig
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17829-7

Internet

https://doi.org/10.1038/s41467-020-17829-7

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