Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17829-7 |
| _version_ | 1818845003662753792 |
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| author | Jack D. Adderley Simona John von Freyend Sarah A. Jackson Megan J. Bird Amy L. Burns Burcu Anar Tom Metcalf Jean-Philippe Semblat Oliver Billker Danny W. Wilson Christian Doerig |
| author_facet | Jack D. Adderley Simona John von Freyend Sarah A. Jackson Megan J. Bird Amy L. Burns Burcu Anar Tom Metcalf Jean-Philippe Semblat Oliver Billker Danny W. Wilson Christian Doerig |
| author_sort | Jack D. Adderley |
| collection | DOAJ |
| description | Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation. |
| first_indexed | 2024-12-19T05:22:45Z |
| format | Article |
| id | doaj.art-2184f8c6d5224440bbad4ee6681c855d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:22:45Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2184f8c6d5224440bbad4ee6681c855d2022-12-21T20:34:27ZengNature PortfolioNature Communications2041-17232020-08-0111111310.1038/s41467-020-17829-7Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial interventionJack D. Adderley0Simona John von Freyend1Sarah A. Jackson2Megan J. Bird3Amy L. Burns4Burcu Anar5Tom Metcalf6Jean-Philippe Semblat7Oliver Billker8Danny W. Wilson9Christian Doerig10Centre for Chronic Inflammatory and Infectious and Diseases, Biomedical Sciences Cluster, School of Health and Biomedical Sciences, RMIT UniversityInfection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash UniversityInfection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash UniversityInfection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash UniversityResearch Centre for Infectious Diseases, School of Biological Sciences, University of AdelaideWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteInstitut National de la Transfusion Sanguine, Inserm UMR S1134Wellcome Trust Sanger InstituteResearch Centre for Infectious Diseases, School of Biological Sciences, University of AdelaideCentre for Chronic Inflammatory and Infectious and Diseases, Biomedical Sciences Cluster, School of Health and Biomedical Sciences, RMIT UniversityPlasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation.https://doi.org/10.1038/s41467-020-17829-7 |
| spellingShingle | Jack D. Adderley Simona John von Freyend Sarah A. Jackson Megan J. Bird Amy L. Burns Burcu Anar Tom Metcalf Jean-Philippe Semblat Oliver Billker Danny W. Wilson Christian Doerig Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention Nature Communications |
| title | Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention |
| title_full | Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention |
| title_fullStr | Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention |
| title_full_unstemmed | Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention |
| title_short | Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention |
| title_sort | analysis of erythrocyte signalling pathways during plasmodium falciparum infection identifies targets for host directed antimalarial intervention |
| url | https://doi.org/10.1038/s41467-020-17829-7 |
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