Lipid nanoparticle-encapsulated DNA vaccine robustly induce superior immune responses to the mRNA vaccine in Syrian hamsters

Lipid nanoparticle-encapsulated DNA vaccine robustly induce superior immune responses to the mRNA vaccine in Syrian hamsters

DNA vaccines for infectious diseases and cancer have been explored for years. To date, only one DNA vaccine (ZyCoV-D) has been authorized for emergency use in India. DNA vaccines are inexpensive and long-term thermostable, however, limited by the low efficiency of intracellular delivery. The recent...

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Bibliographic Details
Main Authors: Hung-Chun Liao, Kuan-Yin Shen, Chung-Hsiang Yang, Fang-Feng Chiu, Chen-Yi Chiang, Kit Man Chai, Wan-Chun Huang, Hui-Min Ho, Yi-Hua Chen, Min-Syuan Huang, Ching-Len Liao, Hsin-Wei Chen, Ming-Hsi Huang, Shih-Jen Liu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lipid nanoparticle
mRNA vaccine
DNA vaccine
DNA delivery
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123002085

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http://www.sciencedirect.com/science/article/pii/S2329050123002085

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