Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis?
Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after radiotherapy, and the radiation-induced fibroatrop...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Dental Hypotheses |
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| Online Access: | http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2013;volume=4;issue=4;spage=122;epage=126;aulast=Zhuang |
| _version_ | 1819212430864023552 |
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| author | Qian Wei Zhuang Zhi Yuan Zhang Guang Long Liu Shui Ting Fu Yue He |
| author_facet | Qian Wei Zhuang Zhi Yuan Zhang Guang Long Liu Shui Ting Fu Yue He |
| author_sort | Qian Wei Zhuang |
| collection | DOAJ |
| description | Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after radiotherapy, and the radiation-induced fibroatrophic mechanism includes the free-radical formation, endothelial dysfunction, inflammation, microvascular thrombosis, fibrosis and remodeling, and finally bone and tissue necrosis. The Hypothesis: Previous studies revealed that transforming growth factor-β1 (TGF-β1) is the master switch cytokine responsible for the regulation of fibroblast proliferation and differentiation that result in RIF. Among the targets of TGF-β1, connective tissue growth factor (CTGF) is a downstream mediator through the Smad3/4 pathway and plays an important role in connective tissue homeostasis and fibroblast proliferation. Studies have proved that the TGF-β1/Smad/CTGF signaling pathway is involved in the RIF of soft tissues, so the authors put forward a hypothesis that the TGF-β1/Smad/CTGF axis is also the main pathway in RIF of ORN. Evaluation of the Hypothesis: The validation of our hypothesis may provide new insights for better understanding the pathogenesis of ORN and open new perspectives for anti-fibrotic therapies, and pioneer novel approaches to treat ORN. |
| first_indexed | 2024-12-23T06:42:51Z |
| format | Article |
| id | doaj.art-2188426273ff4f40912cb28cd097bbf6 |
| institution | Directory Open Access Journal |
| issn | 2155-8213 |
| language | English |
| last_indexed | 2024-12-23T06:42:51Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Hypotheses |
| spelling | doaj.art-2188426273ff4f40912cb28cd097bbf62022-12-21T17:56:39ZengWolters Kluwer Medknow PublicationsDental Hypotheses2155-82132013-01-014412212610.4103/2155-8213.122673Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis?Qian Wei ZhuangZhi Yuan ZhangGuang Long LiuShui Ting FuYue HeIntroduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after radiotherapy, and the radiation-induced fibroatrophic mechanism includes the free-radical formation, endothelial dysfunction, inflammation, microvascular thrombosis, fibrosis and remodeling, and finally bone and tissue necrosis. The Hypothesis: Previous studies revealed that transforming growth factor-β1 (TGF-β1) is the master switch cytokine responsible for the regulation of fibroblast proliferation and differentiation that result in RIF. Among the targets of TGF-β1, connective tissue growth factor (CTGF) is a downstream mediator through the Smad3/4 pathway and plays an important role in connective tissue homeostasis and fibroblast proliferation. Studies have proved that the TGF-β1/Smad/CTGF signaling pathway is involved in the RIF of soft tissues, so the authors put forward a hypothesis that the TGF-β1/Smad/CTGF axis is also the main pathway in RIF of ORN. Evaluation of the Hypothesis: The validation of our hypothesis may provide new insights for better understanding the pathogenesis of ORN and open new perspectives for anti-fibrotic therapies, and pioneer novel approaches to treat ORN.http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2013;volume=4;issue=4;spage=122;epage=126;aulast=ZhuangConnective tissue growth factorosteoradionecrosisradiation-induced fibrosistransforming growth factor-β1/Smad/connective tissue growth factor axistransforming growth factor-β1 |
| spellingShingle | Qian Wei Zhuang Zhi Yuan Zhang Guang Long Liu Shui Ting Fu Yue He Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis? Dental Hypotheses Connective tissue growth factor osteoradionecrosis radiation-induced fibrosis transforming growth factor-β1/Smad/connective tissue growth factor axis transforming growth factor-β1 |
| title | Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis? |
| title_full | Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis? |
| title_fullStr | Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis? |
| title_full_unstemmed | Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis? |
| title_short | Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis? |
| title_sort | transforming growth factor β1 smad connective tissue growth factor axis the main pathway in radiation induced fibrosis of osteoradionecrosis |
| topic | Connective tissue growth factor osteoradionecrosis radiation-induced fibrosis transforming growth factor-β1/Smad/connective tissue growth factor axis transforming growth factor-β1 |
| url | http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2013;volume=4;issue=4;spage=122;epage=126;aulast=Zhuang |
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