The 3′ Non-Coding Sequence Negatively Regulates PD-L1 Expression, and Its Regulators Are Systematically Identified in Pan-Cancer

The 3′ Non-Coding Sequence Negatively Regulates PD-L1 Expression, and Its Regulators Are Systematically Identified in Pan-Cancer

The 3′-untranslated region (3′-UTR) of PD-L1 is significantly longer than the coding sequences (CDSs). However, its role and regulators have been little studied. We deleted whole 3′-UTR region by CRISPR-Cas9. Prognostic analysis was performed using online tools. Immune infiltration analysis was perf...

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Bibliographic Details
Main Authors: Zike Chen, Hui Pi, Wen Zheng, Xiaohong Guo, Conglin Shi, Zhiyang Wang, Jie Zhang, Xuanhao Qu, Lehan Liu, Haoliang Shen, Yang Lu, Miaomiao Chen, Weibing Zhang, Rong Sun, Yihui Fan
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Genes
Subjects:
3′-untranslated region (3′-UTR)
PD-L1
RNA-binding proteins (RBPs)
miRNAs
m6A regulator
Online Access:https://www.mdpi.com/2073-4425/14/8/1620

Internet

https://www.mdpi.com/2073-4425/14/8/1620

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