The landscape of BRAF transcript and protein variants in human cancer

The landscape of BRAF transcript and protein variants in human cancer

Abstract Background The BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood. Results Taking advantage of the RNA-seq data of more than 4800 patients belonging to 9 different cancer types, we show that...

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Bibliographic Details
Main Authors: Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino, Laura Comelli, Samanta Sarti, Simone Lubrano, Cinzia Franchin, Ileabett Echevarría-Vargas, Andrea Tuccoli, Alberto Mercatanti, Monica Evangelista, Paolo Sportoletti, Giorgio Cozza, Ettore Luzi, Enrico Capobianco, Jessie Villanueva, Giorgio Arrigoni, Giovanni Signore, Silvia Rocchiccioli, Letizia Pitto, Nicholas Tsinoremas, Laura Poliseno
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Molecular Cancer
Subjects:
BRAF
RNA-sequencing
Exon-spanning reads
Melanoma
Transcript variants
Protein variants
Online Access:http://link.springer.com/article/10.1186/s12943-017-0645-4

Internet

http://link.springer.com/article/10.1186/s12943-017-0645-4

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