Genista cephalantha Spach. protects against acetaminophen-induced liver failure via preserving the glutathione redox system, reducing inflammatory response, and inhibiting hepatocyte death in rats

Genista cephalantha Spach. protects against acetaminophen-induced liver failure via preserving the glutathione redox system, reducing inflammatory response, and inhibiting hepatocyte death in rats

Objective(s): The current study was conducted to assess the protective mechanisms of n-BuOH fraction from the aerial part of Genista cephontala (BEGC) on APAP-induced liver injury compared to necrostatine-1 (Nec-1).Materials and Methods: A model of APAP-induced hepatotoxicity was created in male rat...

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Bibliographic Details
Main Authors: Boulkandoul Ramzi, Ameddah Souad, Chebbah Kawthar, Erenler Ramazan, Mekkiou Ratiba, Benayache Samir, Benayache Fadila, Ahmed Menad
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2024-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
acetaminophen
cell death
hepatoprotection inflammation
lc-ms/ms
necroptosis
necrostatin-1
oxidative stress
Online Access:https://ijbms.mums.ac.ir/article_23766_4ec018fd1ed5235091bfca3ae93c4cb3.pdf

Internet

https://ijbms.mums.ac.ir/article_23766_4ec018fd1ed5235091bfca3ae93c4cb3.pdf

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