ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and the recruitment of innate immune cells to the pancre...

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Main Authors: Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, Alexandra Coomans de Brachène, Angela Castela, Maikel Colli, Piero Marchetti, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
beta cell (β cell)
inflammation
T1D (type 1 diabetes)
transcriptome
RNA editing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1058345/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.1058345/full

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