Microarray and Biochemical Analysis of Lovastatin-induced Apoptosis of Squamous Cell Carcinomas

Microarray and Biochemical Analysis of Lovastatin-induced Apoptosis of Squamous Cell Carcinomas

We recently identified 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of the mevalonate pathway, as a potential therapeutic target of the head and neck squamous cell carcinomas (HNSCC) and cervical carcinomas (CC). The products of this complex biochemical pathway...

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Bibliographic Details
Main Authors: Jim Dimitroulakos, Wilson H. Marhin, Jason Tokunaga, Jonathan Irish, Patrick Gullane, Linda Z. Penn, Suzanne Kamel-Reid
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
HMG-CoA reductase
lovastatin
apoptosis
squamous cell carcinoma
geranylgeranyl
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860280029X

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http://www.sciencedirect.com/science/article/pii/S147655860280029X

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