Dual orexin receptor antagonists for treatment of insomnia: A systematic review and meta-analysis on randomized, double-blind, placebo-controlled trials of suvorexant and lemborexant

Dual orexin receptor antagonists for treatment of insomnia: A systematic review and meta-analysis on randomized, double-blind, placebo-controlled trials of suvorexant and lemborexant

Study objectivesRecent treatment guidelines for chronic insomnia recommend pharmacological and non-pharmacological therapies. One of the contemporary drug options for insomnia includes dual orexin receptor antagonist (DORA), such as suvorexant and lemborexant. We conducted a systematic review and me...

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Bibliographic Details
Main Authors: Habibolah Khazaie, Masoud Sadeghi, Sepideh Khazaie, Max Hirshkowitz, Amir Sharafkhaneh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Psychiatry
Subjects:
insomnia
orexin receptor antagonist
suvorexant
lemborexant
randomized trial
meta-analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1070522/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1070522/full

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