The impact of inflammation and immune activation on B cell differentiation during HIV-1 infection

The impact of inflammation and immune activation on B cell differentiation during HIV-1 infection

HIV-1 infection is characterized by continuous antigenic stimulation, chronic immune activation and impaired survival of T and B cells. A decline of resting memory B cells has previously been reported to occur in both children and adults infected with HIV-1; these cells are responsible for mounting...

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Bibliographic Details
Main Authors: Nicolas eRuffin, Thang eHong Pham, Bence eRethi, Anna eNilsson, Francesca eChiodi
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Immunology
Subjects:
Germinal Center
HIV-1
Hypergammaglobulinemia
B cells
immune activation
serological memory
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00090/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00090/full

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