SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication

SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication

ABSTRACTYTH N6-methyladenosine RNA-binding protein F2 (YTHDF2) is a member of the YTH protein family that binds to N6-methyladenosine (m6A)-modified RNA, regulating RNA stability and restricting viral replication, including Epstein-Barr virus (EBV). PIAS1 is an E3 small ubiquitin-like modifier (SUMO...

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Bibliographic Details
Main Authors: Febri Gunawan Sugiokto, Farjana Saiada, Kun Zhang, Renfeng Li
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
PIAS1
YTHDF2
restriction factor
Epstein-Barr virus
SUMOylation
m6A
Online Access:https://journals.asm.org/doi/10.1128/mbio.03168-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03168-23

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