Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis
<p>Abstract</p> <p>In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since elevated TNF-α levels are found during active phases of sarcoidosis...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2001-10-01
|
| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/rr178 |
| _version_ | 1828470947345072128 |
|---|---|
| author | Seitzer Ulrike Gerdes Johannes Müller-Quernheim Joachim |
| author_facet | Seitzer Ulrike Gerdes Johannes Müller-Quernheim Joachim |
| author_sort | Seitzer Ulrike |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since elevated TNF-α levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-α levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-α production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease.</p> |
| first_indexed | 2024-12-11T05:02:47Z |
| format | Article |
| id | doaj.art-218deeda012e4368a5c450253b4d6335 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-11T05:02:47Z |
| publishDate | 2001-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-218deeda012e4368a5c450253b4d63352022-12-22T01:20:07ZengBMCRespiratory Research1465-99212001-10-0131610.1186/rr178Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosisSeitzer UlrikeGerdes JohannesMüller-Quernheim Joachim<p>Abstract</p> <p>In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since elevated TNF-α levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-α levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-α production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease.</p>http://dx.doi.org/10.1186/rr178disease haplotypesgene polymorphismsHLA-DRtumor necrosis factor-α |
| spellingShingle | Seitzer Ulrike Gerdes Johannes Müller-Quernheim Joachim Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis Respiratory Research disease haplotypes gene polymorphisms HLA-DR tumor necrosis factor-α |
| title | Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis |
| title_full | Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis |
| title_fullStr | Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis |
| title_full_unstemmed | Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis |
| title_short | Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis |
| title_sort | genotyping in the mhc locus potential for defining predictive markers in sarcoidosis |
| topic | disease haplotypes gene polymorphisms HLA-DR tumor necrosis factor-α |
| url | http://dx.doi.org/10.1186/rr178 |
| work_keys_str_mv | AT seitzerulrike genotypinginthemhclocuspotentialfordefiningpredictivemarkersinsarcoidosis AT gerdesjohannes genotypinginthemhclocuspotentialfordefiningpredictivemarkersinsarcoidosis AT mullerquernheimjoachim genotypinginthemhclocuspotentialfordefiningpredictivemarkersinsarcoidosis |