An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.

An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.

Although the accumulation of amyloidogenic proteins in neuroinflammatory conditions is generally considered pathologic, in a murine model of multiple sclerosis, amyloid-forming fibrils, comprised of hexapeptides, are anti-inflammatory. Whether these molecules modulate systemic inflammatory condition...

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Bibliographic Details
Main Authors: Sidharth Mahapatra, Lihua Ying, Peggy Pui-Kay Ho, Michael Kurnellas, Jonathan Rothbard, Lawrence Steinman, David N Cornfield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6039005?pdf=render

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http://europepmc.org/articles/PMC6039005?pdf=render

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