An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.
Although the accumulation of amyloidogenic proteins in neuroinflammatory conditions is generally considered pathologic, in a murine model of multiple sclerosis, amyloid-forming fibrils, comprised of hexapeptides, are anti-inflammatory. Whether these molecules modulate systemic inflammatory condition...
Main Authors: | Sidharth Mahapatra, Lihua Ying, Peggy Pui-Kay Ho, Michael Kurnellas, Jonathan Rothbard, Lawrence Steinman, David N Cornfield |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC6039005?pdf=render |
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