Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas

Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas

Abstract Background Multi-omics studies have shown a high and lack of common driver mutations in most thymomas (TH) and thymic carcinomas (TC) that hamper the development of novel treatment approaches. However, deregulation of apoptosis has been proposed as a common hallmark of TH and TC. BH3 profil...

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Bibliographic Details
Main Authors: Denise Müller, Paolo Mazzeo, Raphael Koch, Mark-Sebastian Bösherz, Stefan Welter, Alexander von Hammerstein-Equord, Marc Hinterthaner, Lucia Cordes, Djeda Belharazem, Alexander Marx, Philipp Ströbel, Stefan Küffer
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Medicine
Subjects:
MCL-1
BCL-xL
BH3 mimetics
Thymoma
Thymic carcinoma
Online Access:https://doi.org/10.1186/s12916-021-02158-3

Internet

https://doi.org/10.1186/s12916-021-02158-3

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