TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

Abstract We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibited the proliferation of Ph+ cell lines. Tspan32 overexpression significant...

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Bibliographic Details
Main Authors: Qiang Qiu, Yuanyuan Sun, Linyu Yang, Qingqing Li, Yunyu Feng, Mengyuan Li, Yuexia Yin, Li Zheng, Ning Li, Huandi Qiu, Xue Cui, Wei He, Bochuan Wang, Cong Pan, Zi Wang, Juan Huang, Klarke M. Sample, Zhihui Li, Yiguo Hu
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01290-7

Internet

https://doi.org/10.1038/s41392-022-01290-7

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