Toward a Traceless Tag for the Thiol‐Mediated Uptake of Proteins

Toward a Traceless Tag for the Thiol‐Mediated Uptake of Proteins

Abstract The emergence of thiol‐mediated uptake (TMU) as a powerful strategy to penetrate cells calls for the development of practical small‐molecule TMU tools for traceless delivery. Toward this goal, esters are explored here as bioreversible linkers between dynamic covalent cascade exchangers acco...

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Bibliographic Details
Main Authors: Dr. John R. J. Maynard, Dr. Saidbakhrom Saidjalolov, Marie‐Claire Velluz, Stefania Vossio, Prof. Charlotte Aumeier, Dr. Dimitri Moreau, Dr. Naomi Sakai, Prof. Stefan Matile
Format: Article
Language:English
Published: Wiley-VCH 2023-11-01
Series:ChemistryEurope
Subjects:
bioconjugation
bioreversible esterification
isoelectric precipitation
protein delivery
spheroids
thiol-mediated uptake
Online Access:https://doi.org/10.1002/ceur.202300029

Internet

https://doi.org/10.1002/ceur.202300029

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