Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration

Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration

Hand injuries often result in significant functional impairments and are rarely completely restored. The spontaneous regeneration of injured appendages, which occurs in salamanders and newts, for example, has been reported in human fingertips after distal amputation, but this type of regeneration is...

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Bibliographic Details
Main Authors: Zeshaan N. Maan, Yuval Rinkevich, Janos Barrera, Kellen Chen, Dominic Henn, Deshka Foster, Clark Andrew Bonham, Jagannath Padmanabhan, Dharshan Sivaraj, Dominik Duscher, Michael Hu, Kelley Yan, Michael Januszyk, Michael T. Longaker, Irving L. Weissman, Geoffrey C. Gurtner
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Clinical Medicine
Subjects:
digit tip
regeneration
hedgehog signaling
sonic hedgehog
Wnt
rainbow mouse
Online Access:https://www.mdpi.com/2077-0383/10/18/4261

Internet

https://www.mdpi.com/2077-0383/10/18/4261

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