Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways

Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways

Background: Curcumin, the active ingredient in curcuma rhizomes, has a wide range of therapeutic effects. However, its atheroprotective activity in human acute monocytic leukemia THP-1 cells remains unclear. We investigated the activity and molecular mechanism of action of curcumin in polarized macr...

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Bibliographic Details
Main Authors: Yaoyao Zhou, Tiantian Zhang, Xiaofei Wang, Xiaowei Wei, Yizhu Chen, Lingyu Guo, Junfeng Zhang, Changqian Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
MAPK
NF-κB
Atherosclerosis
Curcumin
Macrophage polarization
TLR4
Online Access:http://www.karger.com/Article/FullText/430126

Internet

http://www.karger.com/Article/FullText/430126

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