Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family

Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family

Abstract Background The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such peptide family, sea anemone 8 (SA8), is present in all five sea anemone s...

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Bibliographic Details
Main Authors: Lauren M. Ashwood, Khaled A. Elnahriry, Zachary K. Stewart, Thomas Shafee, Muhammad Umair Naseem, Tibor G. Szanto, Chloé A. van der Burg, Hayden L. Smith, Joachim M. Surm, Eivind A. B. Undheim, Bruno Madio, Brett R. Hamilton, Shaodong Guo, Dorothy C. C. Wai, Victoria L. Coyne, Matthew J. Phillips, Kevin J. Dudley, David A. Hurwood, Gyorgy Panyi, Glenn F. King, Ana Pavasovic, Raymond S. Norton, Peter J. Prentis
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Biology
Subjects:
Sea anemone
Toxin evolution
Genome
Neofunctionalization
Peptide synthesis
Disulfide connectivity
Online Access:https://doi.org/10.1186/s12915-023-01617-y

Internet

https://doi.org/10.1186/s12915-023-01617-y

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